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How to get fromAppleton to Mayo Clinicby plane, bus, car, or taxi

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There are 7 ways to get from Appleton to Mayo Clinic by plane, bus, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Appleton International Airport to Rochester

    best
    1. Fly from Appleton International Airport (ATW) to Rochester (RST)plane plane ATW - RST
    4h 34m
    $65–387

  2. Drive  231.8 mi

    cheapest
    1. Drive from Appleton to Mayo Cliniccar car 231.8 mi
    4h 40m
    $39–56

  3. Bus

    1. Take the bus from Oshkosh to Milwaukeebus bus Lab 211
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    8h 56m
    $138–180

  4. Taxi to Green Bay, fly to Rochester

    1. Take the taxi from Appleton to Green Bay (GRB)taxi taxi
    2. Fly from Green Bay (GRB) to Rochester (RST)plane plane GRB - RST
    5h 5m
    $150–487

  5. Fly Appleton International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Appleton International Airport (ATW) to Minneapolis–Saint Paul International Airport (MSP)plane plane ATW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    4h 41m
    $119–467

  6. Taxi to Green Bay, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the taxi from Appleton to Green Bay (GRB)taxi taxi
    2. Fly from Green Bay (GRB) to Minneapolis–Saint Paul International Airport (MSP)plane plane GRB - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 5m
    $209–567

  7. Taxi, bus

    1. Take the taxi from Appleton to Green Bay Transit Centertaxi taxi
    2. Take the bus from Green Bay Transit Center to Minneapolis Bus Stationbus bus
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 57m
    $224–276

Appleton International Airport (ATW) to Rochester (RST) flights

Calendar49Weekly Planes
Duration4h 44mAverage Duration
Ticket$50Cheapest Price
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Comparing Your Travel Options

Map of how to get from Appleton to Mayo Clinic.ExpandLaunch map view
  • Distance: 213.1 mi
  • Duration: 4h 34m

What companies run services between Appleton, WI, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Appleton International Airport (ATW) to Rochester (RST) every 4 hours. Alternatively, you can take a vehicle from Appleton to Mayo Clinic via Oshkosh, Milwaukee, and Rochester in around 8h 56m.

Airlines
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Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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