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How to get fromChicago to Gainesvilleby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Greyhound)

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There are 10 ways to get from Chicago to Gainesville by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Gainesville Regional Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Gainesville Regional Airport (GNV)plane plane ORD - GNV
    7h 11m
    $70–357

  2. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Gainesvillebus bus FlixBus N2401 / ...
    22h 15m
    $176–269

  3. Train, bus

    1. Take the train from Chicago Union Station to Jacksonvilletrain train Floridian
    2. Take the bus from Jacksonville to Gainesvillebus bus FlixBus 2431
    37h 30m
    $881–1,348

  4. Drive  996.5 mi

    1. Drive from Chicago to Gainesvillecar car 996.5 mi
    18h
    $165–238

  5. Fly Chicago Midway International Airport to Gainesville Regional Airport

    1. Fly from Chicago Midway International Airport (MDW) to Gainesville Regional Airport (GNV)plane plane MDW - GNV
    6h 56m
    $164–557

  6. Fly Chicago Midway International Airport to Jacksonville, bus

    1. Fly from Chicago Midway International Airport (MDW) to Jacksonville (JAX)plane plane MDW - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    8h 6m
    $124–625

  7. Fly Chicago O'Hare International Airport to Jacksonville, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Jacksonville (JAX)plane plane ORD - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    8h 31m
    $80–375

  8. Fly Chicago Midway International Airport to Orlando, bus

    1. Fly from Chicago Midway International Airport (MDW) to Orlando (MCO)plane plane MDW - MCO
    2. Take the bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Drbus bus
    7h 53m
    $204–597

  9. Fly Chicago Midway International Airport to Tampa, bus

    1. Fly from Chicago Midway International Airport (MDW) to Tampa (TPA)plane plane MDW - TPA
    2. Take the bus from Tampa Bus Station to Gainesvillebus bus
    9h 54m
    $134–237

  10. Bus via North Walmart Supercenter (Greyhound)

    1. Take the bus from Chicago Train Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Gainesville Bus Stopbus bus Greyhound US0630
    25h 3m
    $185–281

Chicago to Gainesville by bus

Calendar32Weekly Buses
Duration22h 15mAverage Duration
Ticket$176Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Gainesville.ExpandLaunch map view
  • Distance: 930.4 mi
  • Duration: 7h 11m

What companies run services between Chicago, IL, USA and Gainesville, FL, USA?

Delta and American Airlines fly from Chicago O'Hare International Airport (ORD) to Gainesville Regional Airport (GNV) every 3 hours. Alternatively, you can take a bus from Chicago Bus Station to Gainesville via Atlanta Bus Station in around 22h 15m.

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Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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