There are 6 ways to get from Chicago to Murphysboro by train (Amtrak), bus (Flixbus, Amtrak), car, plane, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Chicago Union Station to Carbondaletrain Saluki / ...
5h 40m$189–284Fly to Barkley Regional Airport, drive
cheapest- Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane ORD - PAH
- Drive from Barkley Regional Airport (PAH) to Murphysborocar
4h 40m$54–294Bus
- Take the bus from Chicago Bus Station to St Louis Bus Stationbus FlixBus 2510 / ...
- Take the bus from St. Louis to Carbondalebus Amtrak Thruway Connecting Service
9h 5m$85–121Drive 331.7 mi
- Drive from Chicago to Murphysborocar 331.7 mi
5h 43m$55–80Fly to Williamson County Regional Airport
- Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane ORD - MWA
3h 38m$128–275Fly to Cape Girardeau Municipal Airport, taxi
- Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)plane ORD - CGI
- Take the taxi from Cape Girardeau Municipal Airport (CGI) to Murphysborotaxi
4h 34m$222–495
Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA) flights
Comparing Your Travel Options
The cheapest way to get from Chicago to Murphysboro is to drive which costs $55 - $80 and takes 5h 43m.
The fastest way to get from Chicago to Murphysboro is to fly which takes 3h 38m and costs $120 - $280.
No, there is no direct bus from Chicago station to Murphysboro. However, there are services departing from Chicago Bus Station and arriving at Carbondale via St. Louis. The journey, including transfers, takes approximately 9h 5m.
No, there is no direct train from Chicago station to Murphysboro. However, there are services departing from Chicago Union Station and arriving at Carbondale via . The journey, including transfers, takes approximately 5h 40m.
The distance between Chicago and Murphysboro is 318 miles. The road distance is 333.7 miles.
The best way to get from Chicago to Murphysboro without a car is to train which takes 5h 40m and costs $180 - $290.
It takes approximately 5h 40m to get from Chicago to Murphysboro, including transfers.
Chicago to Murphysboro bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago to Murphysboro train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from Chicago to Murphysboro is to train which takes 5h 40m and costs $180 - $290. Alternatively, you can bus, which costs $85 - $130 and takes 9h 5m, you could also fly, which costs $120 - $280 and takes 3h 38m.
What companies run services between Chicago, IL, USA and Murphysboro, IL, USA?
Amtrak operates a train from Chicago Union Station to Carbondale 3 times a day. Tickets cost $170–270 and the journey takes 5h 30m. Alternatively, you can take a bus from Chicago Bus Station to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 9h 5m.
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Williamson County Regional Airport
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $40–260
- Website
- contouraviation.com
Flights from Chicago O'Hare International Airport to Cape Girardeau Municipal Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $110–350
- Website
- united.com
Flights from Chicago O'Hare International Airport to Barkley Regional Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $40–270
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Chicago Union Station to Carbondale
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $170–270
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 55m
- Frequency
- Twice daily
- Estimated price
- $50–75
- Schedules at
- Flixbus USA
Bus from St. Louis to Carbondale
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- $15–23
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from St. Louis to Carbondale
- Ave. Duration
- 2h
- Frequency
- Once daily
- Website
- Amtrak
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Booking & Getting There
Chicago to Murphysboro bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
Chicago to Murphysboro train services, operated by Amtrak, arrive at Carbondale station.
Yes, the driving distance between Chicago to Murphysboro is 334 miles. It takes approximately 5h 43m to drive from Chicago to Murphysboro.
There are 33+ hotels available in Murphysboro.