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How to get fromDenver to Santa Anaby plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

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There are 10 ways to get from Denver to Santa Ana by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Denver (DEN) to John Wayne Airport Orange County (SNA)plane plane DEN - SNA
    5h 8m
    $119–378

  2. Fly to Long Beach Airport, bus

    cheapest
    1. Fly from Denver (DEN) to Long Beach Airport (LGB)plane plane DEN - LGB
    2. Take the bus from Long Beach Downtown Transit Gallery to Santa Ana Bus Stopbus bus
    7h 15m
    $82–403

  3. Bus (Greyhound)

    1. Take the bus from Denver Union Station to Las Vegas Bus Terminalbus bus Greyhound US1200
    2. Take the bus from Las Vegas Bus Terminal to Santa Ana Bus Stopbus bus Greyhound US0900
    21h 55m
    $182–277

  4. Bus, train

    1. Take the bus from Denver to Las Vegas Transportation Centerbus bus Denver / ...
    2. Take the train from Las Vegas Amtrak Station to Fullerton Amtrak Stationtrain train Southwest Chief
    27h 11m
    $629–950

  5. Drive  1,013.3 mi

    1. Drive from Denver to Santa Anacar car 1,013.3 mi
    15h 51m
    $168–242

  6. Fly to Los Angeles International Airport, train

    1. Fly from Denver (DEN) to Los Angeles International Airport (LAX)plane plane DEN - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    6h 49m
    $123–560

  7. Fly to San Diego International Airport, train

    1. Fly from Denver (DEN) to San Diego International Airport (SAN)plane plane DEN - SAN
    2. Take the train from San Diego to Santa Anatrain train
    7h 31m
    $202–440

  8. Fly to Burbank Bob Hope Airport, train

    1. Fly from Denver (DEN) to Burbank Bob Hope Airport (BUR)plane plane DEN - BUR
    2. Take the train from Los Angeles to Santa Anatrain train
    7h 32m
    $205–350

  9. Fly to Palm Springs International Airport, bus

    1. Fly from Denver (DEN) to Palm Springs International Airport (PSP)plane plane DEN - PSP
    2. Take the bus from Palm Springs Airport Amtrak Bus Stop to Fullerton Amtrak Stationbus bus
    8h 9m

  10. Bus via Artic - Dock 4

    1. Take the bus from Denver Union Station to Las Vegas Bus Terminalbus bus Greyhound US1200
    2. Take the bus from Las Vegas Strip to Anaheim Regional Transportation Intermodal Centerbus bus FlixBus 2030 / ...
    24h 3m
    $190–281

Denver to Santa Ana by bus (Greyhound)

Calendar7Weekly Buses
Duration21h 55mAverage Duration
Ticket$182Cheapest Price
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Comparing Your Travel Options

Map of how to get from Denver to Santa Ana.ExpandLaunch map view
  • Distance: 872.7 mi
  • Duration: 5h 8m

What companies run services between Denver, CO, USA and Santa Ana, CA, USA?

Frontier Airlines, United Airlines, and Southwest Airlines fly from Denver (DEN) to John Wayne Airport Orange County (SNA) hourly. Alternatively, you can take a bus from Denver Union Station to Santa Ana Bus Stop via Las Vegas Bus Terminal in around 21h 55m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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