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How to get fromDepew to Pittsburghby bus (Flixbus, Greyhound), train (Amtrak), car, plane, or bus

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There are 5 ways to get from Depew to Pittsburgh by bus (Flixbus, Greyhound), train (Amtrak), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Erie

    best
    1. Take the bus from Buffalo to Eriebus bus FlixBus 2526
    2. Take the bus from Erie to Pittsburgh Intermodal Stationbus bus Greyhound US0440s
    8h 14m
    $40–67

  2. Drive  219.4 mi

    cheapest
    1. Drive from Depew to Pittsburghcar car 219.4 mi
    3h 50m
    $37–53

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Cleveland Amtraktrain train Lake Shore Limited
    2. Take the train from Cleveland Amtrak to Pittsburgh Amtrak Stationtrain train Floridian
    8h 31m
    $177–282

  4. Fly

    1. Fly from Buffalo Niagara International Airport (BUF) to Pittsburgh International Airport (PIT)plane plane BUF - PIT
    5h 3m
    $87–460

  5. Bus

    1. Take the bus from Buffalo to Pittsburghbus bus Fab530
    9h 29m
    $72–242

Depew to Pittsburgh by bus

Calendar7Weekly Buses
Duration8h 14mAverage Duration
Ticket$40Cheapest Price
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Comparing Your Travel Options

Map of how to get from Depew to Pittsburgh.ExpandLaunch map view
  • Distance: 244.7 mi
  • Duration: 8h 14m

What companies run services between Depew, NY, USA and Pittsburgh, PA, USA?

You can take a bus from Broadway & Meridian Street to Pittsburgh Intermodal Station via Buffalo and Erie in around 8h 14m. Alternatively, you can take a bus from Broadway & Meridian Street to Pittsburgh Amtrak Station via Dick Road & AMTRAK Station, Buffalo Depew Station, and Cleveland Amtrak in around 8h 31m.

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