Rome2Rio

How to get fromIowa to Tupeloby plane, bus (Greyhound, Flixbus), car, bus (Greyhound, Amtrak, Flixbus), bus, or train

Find Transport to Tupelo

See all options
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

There are 7 ways to get from Iowa to Tupelo by plane, bus (Greyhound, Flixbus), car, bus (Greyhound, Amtrak, Flixbus), bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Tupelo Regional Airport

    best
    1. Fly from Des Moines (DSM) to Tupelo Regional Airport (TUP)plane plane DSM - TUP
    4h 29m
    $103–441

  2. Fly Quad City International Airport to Golden Triangle Regional Airport, drive

    cheapest
    1. Fly from Quad City International Airport (MLI) to Golden Triangle Regional Airport (GTR)plane plane MLI - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    8h 27m
    $92–447

  3. Bus via Kansas City

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    17h 44m
    $167–263

  4. Drive  681.7 mi

    1. Drive from Des Moines to Tupelocar car 681.7 mi
    12h 45m
    $113–163

  5. Fly Omaha to Tupelo Regional Airport

    1. Fly from Omaha (OMA) to Tupelo Regional Airport (TUP)plane plane OMA - TUP
    7h 27m
    $107–501

  6. Bus

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    18h 46m

  7. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the train from Kansas City to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    20h 4m
    $277–433

Des Moines (DSM) to Tupelo Regional Airport (TUP) flights

Calendar15Weekly Planes
Duration6h 10mAverage Duration
Ticket$73Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Iowa to Tupelo.ExpandLaunch map view
  • Distance: 578.9 mi
  • Duration: 4h 29m

What companies run services between Iowa, USA and Tupelo, MS, USA?

Southwest Airlines, Corporate Flight Management Inc, and three other airlines fly from Des Moines (DSM) to Tupelo Regional Airport (TUP) twice daily. Alternatively, you can take a bus from Des Moines to Tupelo via Kansas City, Kansas City Bus Station, St Louis Bus Station, Memphis Bus Station, and Tupelo in around 17h 44m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There