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How to get fromIsernia to Milanby train (Trenitalia), bus, car, train, or plane

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There are 11 ways to get from Isernia to Milan by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Milano Centraletrain train Fr / ...
    5h 53m
    €82–160

  2. Bus, bus to Abruzzo Airport, fly to Milano Malpensa Airport, train

    cheapest
    1. Take the bus from Isernia to San Salvo Marinabus bus
    2. Take the bus from San Salvo Marina to Pescara Airportbus bus
    3. Fly from Abruzzo Airport (PSR) to Milano Malpensa Airport (MXP)plane plane PSR - MXP
    4. Take the train from Malpensa Aeroporto T1 to Milano Porta Garibalditrain train
    7h 3m
    €33–147

  3. Bus

    1. Take the bus from Isernia to Termoli Terminal Busbus bus Cb 014
    2. Take the bus from Termoli Autostazione to Milano, San Donato M3bus bus Vieste
    10h 25m
    €56–103

  4. Drive  711.7 km

    1. Drive from Isernia to Milancar car 711.7 km
    7h 8m
    €128–185

  5. Train to Fiumicino International Airport, fly to Milan Linate Airport

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Milan Linate Airport (LIN)plane plane FCO - LIN
    5h 25m
    €81–219

  6. Bus via Florence

    1. Take the bus from Isernia to Florence Villa Constanza Bus Stationbus bus 433
    2. Take the bus from Florence Villa Constanza Bus Station to Milano, San Donato M3bus bus N528 / ...
    14h 20m
    €71–125

  7. Train to Naples Airport, fly to Milan Linate Airport

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Milan Linate Airport (LIN)plane plane NAP - LIN
    5h 6m
    €69–212

  8. Bus to Foggia Gino Lisa Airport, fly to Milan Linate Airport

    1. Take the bus from Isernia to Foggiabus bus
    2. Fly from Foggia Gino Lisa Airport (FOG) to Milan Linate Airport (LIN)plane plane FOG - LIN
    5h 26m
    €100–276

  9. Train to Naples Airport, fly to Milano Malpensa Airport, train

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Milano Malpensa Airport (MXP)plane plane NAP - MXP
    3. Take the train from Malpensa Aeroporto T1 to Milano Porta Garibalditrain train
    6h 5m
    €35–185

  10. Train, train to Salerno Costa D'Amalfi Airport, fly to Milan Linate Airport

    1. Take the train from Isernia to Casertatrain train
    2. Take the train from Caserta to Salernotrain train
    3. Fly from Salerno Costa D'Amalfi Airport (QSR) to Milan Linate Airport (LIN)plane plane QSR - LIN
    7h 6m
    €101–209

  11. Train to Fiumicino International Airport, fly to Genoa Cristoforo Colombo Airport, train

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Genoa Cristoforo Colombo Airport (GOA)plane plane FCO - GOA
    3. Take the train from Genova P.Za Principe to Milano Centraletrain train
    7h 36m
    €85–236

Isernia to Milan by train

Calendar58Weekly Trains
Duration5h 53mAverage Duration
Ticket€82Cheapest Price
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Comparing Your Travel Options

Map of how to get from Isernia to Milan.ExpandLaunch map view
  • Distance: 747.2 km
  • Duration: 5h 53m

What companies run services between Isernia, Italy and Milan, Italy?

You can take a train from Isernia to Milano Centrale via Roma Termini in around 5h 53m. Alternatively, you can take a bus from Isernia to Milano, San Donato M3 via Termoli Autostazione in around 10h 25m.

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