There are 6 ways to get from Mainz to Lyon by plane, train (TGV), train, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Frankfurt
best- Fly from Frankfurt (FRA) to Lyon–Saint Exupéry Airport (LYS)plane FRA - LYS
4h 29m€130–348Train, bus
cheapest- Take the train from Mainz, Hauptbahnhof to Saarbrücken Hbftrain Re3 / ...
- Take the bus from Saarbrücken bus station to Lyonbus N235
10h 45m€74–111Train
- Take the train from Mainz, Hauptbahnhof to Karlsruhe Hauptbahnhoftrain Re4
- Take the train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhoftrain 83 / ...
- Take the train from Strasbourg to Lyon Part Dieutrain Tgv
8h 35m€130–216Drive 652.8 km
- Drive from Mainz to Lyoncar 652.8 km
6h 2m€120–173Train to Düsseldorf International Airport, fly
- Take the train from Mainz Hbf to Duesseldorf Hbftrain
- Fly from Düsseldorf International Airport (DUS) to Lyon–Saint Exupéry Airport (LYS)plane DUS - LYS
6h 55m€133–353Bus
- Take the bus from FRANKFURT AM MAIN, Hbf Südseite - Pforzheimer Str. to LYON, Lyon - Perrache - poziom górny Abus
11h 55m€99–101
Mainz to Lyon by train
Comparing Your Travel Options
The cheapest way to get from Mainz to Lyon is to train and bus which costs €70 - €120 and takes 10h 45m.
The fastest way to get from Mainz to Lyon is to fly which takes 4h 29m and costs €130 - €350.
No, there is no direct bus from Mainz station to Lyon. However, there are services departing from Mainz central train station and arriving at LYON, Lyon - Perrache - poziom górny A via FRANKFURT AM MAIN, Hbf Südseite - Pforzheimer Str.. The journey, including transfers, takes approximately 11h 55m.
No, there is no direct train from Mainz to Lyon. However, there are services departing from Mainz, Hauptbahnhof and arriving at Lyon Part Dieu via Karlsruhe Hauptbahnhof and Strasbourg. The journey, including transfers, takes approximately 8h 35m.
The distance between Mainz and Lyon is 595 km. The road distance is 652.8 km.
The best way to get from Mainz to Lyon without a car is to train which takes 8h 35m and costs €130 - €220.
It takes approximately 4h 29m to get from Mainz to Lyon, including transfers.
Mainz to Lyon bus services, operated by Sindbad, depart from FRANKFURT AM MAIN, Hbf Südseite - Pforzheimer Str. station.
Mainz to Lyon train services, operated by Süwex, depart from Mainz, Hauptbahnhof station.
The best way to get from Mainz to Lyon is to fly which takes 4h 29m and costs €130 - €350. Alternatively, you can train, which costs €130 - €220 and takes 8h 35m, you could also bus, which costs €99 - €101 and takes 11h 55m.
What companies run services between Mainz, Germany and Lyon, France?
Lufthansa, Airbus France, and three other airlines fly from Frankfurt (FRA) to Lyon–Saint Exupéry Airport (LYS) every 4 hours. Alternatively, you can take a train from Mainz, Hauptbahnhof to Lyon Part Dieu via Karlsruhe Hauptbahnhof, Strasbourg Bahnhof, and Strasbourg in around 8h 35m.
- Website
- lufthansa.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–550
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Munich
- Ave. Duration
- 3h 40m
- When
- Monday, Wednesday, Thursday, and Friday
- Estimated price
- €80–250
Flights from Düsseldorf International Airport to Lyon–Saint Exupéry Airport via Frankfurt
- Ave. Duration
- 3h 27m
- When
- Every day
- Estimated price
- €85–260
Flights from Düsseldorf International Airport to Lyon–Saint Exupéry Airport via Munich
- Ave. Duration
- 3h 50m
- When
- Monday and Tuesday
- Estimated price
- €90–270
- Website
- airbus.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–240
- Website
- airfrance.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Paris Charles de Gaulle
- Ave. Duration
- 3h 35m
- When
- Every day
- Estimated price
- €55–340
Flights from Düsseldorf International Airport to Lyon–Saint Exupéry Airport via Paris Charles de Gaulle
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- €60–360
- Website
- airdolomiti.it
Flights from Frankfurt to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 20m
- When
- Monday to Saturday
- Estimated price
- €170–550
- Website
- brusselsairlines.com
Flights from Frankfurt to Lyon–Saint Exupéry Airport via Brussels
- Ave. Duration
- 3h 20m
- When
- Tuesday, Thursday, Friday, and Sunday
- Estimated price
- €75–280
- Website
- eurowings.com
Flights from Düsseldorf International Airport to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h 30m
- When
- Monday to Thursday
- Estimated price
- €80–280
- Website
- klm.com
Flights from Düsseldorf International Airport to Lyon–Saint Exupéry Airport via Amsterdam Schiphol
- Ave. Duration
- 3h 35m
- When
- Every day
- Estimated price
- €65–370
- Phone
- +49 621 830 1200
- Website
- Süwex
Train from Mainz, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 40m
- Frequency
- Every 4 hours
- Estimated price
- €23–35
- Schedules at
- Süwex
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mainz, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 34m
- Frequency
- 5 times a day
- Estimated price
- €21–45
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhof
- Ave. Duration
- 43 min
- Frequency
- Every 3 hours
- Estimated price
- €13–25
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Mainz Hbf to Duesseldorf Hbf
- Ave. Duration
- 2h 13m
- Frequency
- Hourly
- Estimated price
- €35–65
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Mainz, Hauptbahnhof to Karlsruhe Hauptbahnhof
- Ave. Duration
- 2h 26m
- Frequency
- Every 4 hours
- Estimated price
- €22
- Website
- Deutsche Bahn Regio (DB Regional)
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Strasbourg to Lyon Part Dieu
- Ave. Duration
- 4h 12m
- Frequency
- Every 4 hours
- Estimated price
- €95–140
- Website
- TGV inOui
Rome2Rio's guide to Société Nationale des Chemins de fer Français (SNCF)
Contact Details
- Phone
- +33 1 84 94 36 35
- Website
- Oui.SNCF
Train from Strasbourg to Lyon Part Dieu
- Ave. Duration
- 4h 20m
- Frequency
- Twice daily
- Estimated price
- €95–150
- Website
- Oui.SNCF
- Phone
- +49 6731 999 27-27
- [email protected]
- Website
- vlexx
Train from Mainz, Hauptbahnhof to Saarbrücken Hbf
- Ave. Duration
- 2h 17m
- Frequency
- Hourly
- Estimated price
- €29–45
- Schedules at
- vlexx
- Phone
- +31 30 751 5155
- Website
- Nederlandse Spoorwegen (NS)
Train from Mainz Hbf to Duesseldorf Hbf
- Ave. Duration
- 2h 26m
- Frequency
- Once a week
- Estimated price
- €24–45
- Website
- Nederlandse Spoorwegen (NS)
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Saarbrücken bus station to Lyon
- Ave. Duration
- 7h 5m
- Frequency
- Once daily
- Estimated price
- €45–70
- Website
- Flixbus
- Phone
- +48 77 443 44 44
- [email protected]
- Website
- Sindbad
Bus from FRANKFURT AM MAIN, Hbf Südseite - Pforzheimer Str. to LYON, Lyon - Perrache - poziom górny A
- Ave. Duration
- 10h 10m
- Frequency
- Twice a week
- Estimated price
- €96
- Website
- Sindbad
Want to know more about travelling around France
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Booking & Getting There
Mainz to Lyon bus services, operated by Sindbad, arrive at LYON, Lyon - Perrache - poziom górny A station.
Mainz to Lyon train services, operated by Süwex, arrive at Karlsruhe Hauptbahnhof station.
Yes, the driving distance between Mainz to Lyon is 653 km. It takes approximately 6h 2m to drive from Mainz to Lyon.
Book your Mainz to Lyon train tickets online with Omio.
Book your Mainz to Lyon bus tickets online with Omio.
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