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How to get fromMichigan to St. Louisby plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

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There are 7 ways to get from Michigan to St. Louis by plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Detroit

    best
    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    3h 57m
    $115–705

  2. Fly from Gerald R. Ford International Airport

    cheapest
    1. Fly from Gerald R. Ford International Airport (GRR) to Lambert–St. Louis International Airport (STL)plane plane GRR - STL
    6h 57m
    $82–467

  3. Bus (Greyhound)

    1. Take the bus from Detroit Bus Station to Indianapolis Union Stationbus bus Greyhound US0112
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    10h 30m
    $90–139

  4. Train (Amtrak)

    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    12h 11m
    $304–477

  5. Drive  517 mi

    1. Drive from Detroit to St. Louiscar car 517 mi
    8h 54m
    $86–124

  6. Bus to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Detroit Bus Station to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    6h 57m
    $145–698

  7. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from Detroit Bus Station to Chicagobus bus FlixBus 2552
    2. Take the bus from Chicago to St Louis Bus Stationbus bus FlixBus N2521
    13h 25m
    $99–155

Michigan to St. Louis by bus (Greyhound)

Calendar7Weekly Buses
Duration10h 30mAverage Duration
Ticket$90Cheapest Price
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Comparing Your Travel Options

Map of how to get from Michigan to St. Louis.ExpandLaunch map view
  • Distance: 468.4 mi
  • Duration: 3h 57m

What companies run services between Michigan, USA and St. Louis, MO, USA?

Delta, Southwest Airlines, and two other airlines fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a bus from Detroit Bus Station to St Louis Bus Station via Indianapolis Union Station in around 10h 30m.

Airlines
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Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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