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How to get fromMurrells Inlet to Lake Cityby car, train, bus, bus (Greyhound), or plane

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There are 8 ways to get from Murrells Inlet to Lake City by car, train, bus, bus (Greyhound), or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, train, bus

    best
    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    9h 16m
    $193–307

  2. Drive  371.3 mi

    cheapest
    1. Drive from Murrells Inlet to Lake Citycar car 371.3 mi
    6h 59m
    $62–89

  3. Bus (Greyhound)

    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    2. Take the bus from Camden to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    14h 11m
    $128–192

  4. Fly to Jacksonville, bus

    1. Fly from Myrtle Beach (MYR) to Jacksonville (JAX)plane plane MYR - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    7h 49m
    $107–407

  5. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    10h 28m
    $213–319

  6. Fly to Orlando, bus

    1. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    8h 22m
    $183–307

  7. Fly to Gainesville Regional Airport, bus

    1. Fly from Myrtle Beach (MYR) to Gainesville Regional Airport (GNV)plane plane MYR - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    8h 38m
    $107–403

  8. Fly to Valdosta, bus

    1. Fly from Myrtle Beach (MYR) to Valdosta (VLD)plane plane MYR - VLD
    2. Take the bus from Valdosta to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    9h 17m
    $133–443

Myrtle Beach (MYR) to Jacksonville (JAX) flights

Calendar65Weekly Planes
Duration4h 40mAverage Duration
Ticket$56Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Murrells Inlet to Lake City.ExpandLaunch map view
  • Distance: 432.6 mi
  • Duration: 9h 16m

What companies run services between Murrells Inlet, SC, USA and Lake City, FL, USA?

You can take a vehicle from Murrells Inlet to Lake City Bus Station via Myrtle Beach Bus Station, Camden, and Jacksonville in around 14h 11m.

Airlines
Train operators
Bus operators

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