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How to get fromMyrtle Beach to Chicagoby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 6 ways to get from Myrtle Beach to Chicago by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago O'Hare International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    3h 35m
    $64–309

  2. Bus via Atlanta

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    25h 55m
    $185–286

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    30h 4m
    $617–1,000

  4. Drive  895.5 mi

    1. Drive from Myrtle Beach to Chicagocar car 895.5 mi
    16h 29m
    $148–214

  5. Fly to Chicago Midway International Airport

    1. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    3h 3m
    $89–419

  6. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from Columbus to Chicagobus bus
    26h 55m
    $121–245

Myrtle Beach to Chicago by bus

Calendar7Weekly Buses
Duration25h 55mAverage Duration
Ticket$185Cheapest Price
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Comparing Your Travel Options

Map of how to get from Myrtle Beach to Chicago.ExpandLaunch map view
  • Distance: 773.9 mi
  • Duration: 3h 35m

What companies run services between Myrtle Beach, SC, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Chicago Bus Station via Atlanta Bus Station in around 25h 55m.

Airlines
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Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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Need to know: Greyhound

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