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How to get fromPhiladelphia to Depewby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Greyhound)

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There are 9 ways to get from Philadelphia to Depew by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Philadelphia International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane plane PHL - BUF
    3h 1m
    $150–875

  2. Drive  335.2 mi

    cheapest
    1. Drive from Philadelphia to Depewcar car 335.2 mi
    7h 2m
    $56–80

  3. Train

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the train from New York Penn Station to Buffalotrain train VIA Rail
    11h 28m
    $133–878

  4. Bus

    1. Take the bus from Philadelphia Bus Station to Newark Penn Stationbus bus Greyhound US0421 / ...
    2. Take the bus from Newark Penn Station to Buffalobus bus FlixBus 2686 / ...
    12h 23m
    $75–133

  5. Train to Newark Liberty International Airport, fly

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    3h 50m
    $140–637

  6. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)plane plane BWI - BUF
    3h 58m
    $136–1,279

  7. Train to John F. Kennedy International Airport, fly

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane plane JFK - BUF
    4h 34m
    $112–1,056

  8. Train via Galleria Driveway & Green Parking Entrance (Amtrak)

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalo Depew Stationtrain train Empire Service / ...
    12h 25m
    $255–970

  9. Bus via Scranton (Greyhound)

    1. Take the bus from Philadelphia Bus Station to Scranton Bus Stationbus bus Greyhound US0340s
    2. Take the bus from Scranton Bus Station to Buffalobus bus Greyhound US0205 / ...
    14h 8m
    $73–115

Philadelphia to Depew by train and bus

Calendar5Weekly Services
Duration11h 28mAverage Duration
Ticket$133Cheapest Price
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Comparing Your Travel Options

Map of how to get from Philadelphia to Depew.ExpandLaunch map view
  • Distance: 291.3 mi
  • Duration: 3h 1m

What companies run services between Philadelphia, PA, USA and Depew, NY, USA?

American Airlines and United Airlines fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF) 5 times a day. Alternatively, you can take a train from 30th Street Station to Broadway & Canton Street via Ny Moynihan Train Hall At Penn Station, New York Penn Station, Buffalo, and Broadway & Dick Road in around 11h 28m.

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Want to know more about travelling around United States

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Need to know: Greyhound

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