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How to get fromSt. Louis to Iowaby bus (Greyhound), train, bus, car, plane, or bus (Flixbus, Amtrak, Greyhound)

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There are 7 ways to get from St. Louis to Iowa by bus (Greyhound), train, bus, car, plane, or bus (Flixbus, Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Kansas City

    best
    1. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus Greyhound US0180s / ...
    2. Take the bus from Kansas City to Des Moinesbus bus Jefferson Lines 804 / ...
    8h 25m
    $95–141

  2. Drive  331.1 mi

    cheapest
    1. Drive from St. Louis to Des Moinescar car 331.1 mi
    6h 35m
    $55–79

  3. Train, bus

    1. Take the train from St. Louis to Kansas Citytrain train Missouri River Runner / ...
    2. Take the bus from Kansas City to Des Moinesbus bus Jefferson Lines 804 / ...
    10h 51m
    $203–310

  4. Fly to Des Moines

    1. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane plane STL - DSM
    5h 33m
    $90–456

  5. Bus

    1. Take the bus from St Louis Bus Station to Springfield SMTD Transfer Centerbus bus
    2. Take the bus from Springfield to Galesburg Amtrak Stationbus bus
    3. Take the bus from Galesburg to Des Moinesbus bus
    11h 36m

  6. Fly to Omaha, line 41 bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Omaha (OMA)plane plane STL - OMA
    2. Take the bus from Farnam St & 18th NE to 16th & Broadway NEbus bus
    4h 57m
    $86–556

  7. Fly to Quad City International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Quad City International Airport (MLI)plane plane STL - MLI
    6h 50m
    $64–394

St. Louis to Iowa by bus

Calendar18Weekly Buses
Duration8h 25mAverage Duration
Ticket$95Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Iowa.ExpandLaunch map view
  • Distance: 441.6 mi
  • Duration: 8h 25m

What companies run services between St. Louis, MO, USA and Iowa, USA?

You can take a bus from St Louis Bus Station to Des Moines via Kansas City Bus Station and Kansas City in around 8h 25m. Alternatively, Delta, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM) hourly.

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Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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